论文标题
时间问题：使用动力学和理论来发现转录爆发的机制
A matter of time: Using dynamics and theory to uncover mechanisms of transcriptional bursting
论文作者
论文摘要
真核转录通常发生在持续几分钟到几个小时的活动中。但是，最新的测量结果表明，爆发的许多分子过程，例如与DNA结合的转录因子，在秒的时间尺度上展开。这种时间断开连接在于从基本分子过程的动力学中预测转录结果和细胞决策的物理生物学挑战的核心。在这里，我们回顾了如何将有关转录控制过程的新动态信息与理论模型结合使用，这些模型不仅可以预测平均转录动力学，而且可以预测其可变性，以提出有关转录爆发和控制的分子机制的可检验假设。
Eukaryotic transcription generally occurs in bursts of activity lasting minutes to hours; however, state-of-the-art measurements have revealed that many of the molecular processes that underlie bursting, such as transcription factor binding to DNA, unfold on timescales of seconds. This temporal disconnect lies at the heart of a broader challenge in physical biology of predicting transcriptional outcomes and cellular decision-making from the dynamics of underlying molecular processes. Here, we review how new dynamical information about the processes underlying transcriptional control can be combined with theoretical models that predict not only averaged transcriptional dynamics, but also their variability, to formulate testable hypotheses about the molecular mechanisms underlying transcriptional bursting and control.
