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Convolutional Neural Networks (CNNs) achieved great cognitive performance at the expense of considerable computation load. To relieve the computation load, many optimization works are developed to reduce the model redundancy by identifying and removing insignificant model components, such as weight sparsity and filter pruning. However, these works only evaluate model components' static significance with internal parameter information, ignoring their dynamic interaction with external inputs. With per-input feature activation, the model component significance can dynamically change, and thus the static methods can only achieve sub-optimal results. Therefore, we propose a dynamic CNN optimization framework in this work. Based on the neural network attention mechanism, we propose a comprehensive dynamic optimization framework including (1) testing-phase channel and column feature map pruning, as well as (2) training-phase optimization by targeted dropout. Such a dynamic optimization framework has several benefits: (1) First, it can accurately identify and aggressively remove per-input feature redundancy with considering the model-input interaction; (2) Meanwhile, it can maximally remove the feature map redundancy in various dimensions thanks to the multi-dimension flexibility; (3) The training-testing co-optimization favors the dynamic pruning and helps maintain the model accuracy even with very high feature pruning ratio. Extensive experiments show that our method could bring 37.4% to 54.5% FLOPs reduction with negligible accuracy drop on various of test networks.