论文标题

Gandalf:通过MRI诊断的具有歧视者自适应损失微调的生成对抗网络

GANDALF: Generative Adversarial Networks with Discriminator-Adaptive Loss Fine-tuning for Alzheimer's Disease Diagnosis from MRI

论文作者

Shin, Hoo-Chang, Ihsani, Alvin, Xu, Ziyue, Mandava, Swetha, Sreenivas, Sharath Turuvekere, Forster, Christopher, Cha, Jiook, Initiative, Alzheimer's Disease Neuroimaging

论文摘要

正电子发射断层扫描(PET)现在被视为诊断阿尔茨海默氏病(AD)的黄金标准。但是,在成本和计划方面,PET成像可能会令人过高,并且也是辐射剂量最高的成像技术之一。相反,磁共振成像(MRI)更广泛地可用,并在设置所需图像分辨率时提供了更大的灵活性。不幸的是,由于在MRI上可见的健康和AD受试者之间存在非常细微的生理差异,因此使用MRI的AD诊断很困难。结果,为了使MR诊断为AD,使用生成的对抗网络(GAN)进行了许多尝试从MR图像中合成PET图像。 MRI的现有关于PET合成的工作主要集中在有条件的gan上,其中MR图像用于生成PET图像,并随后用于AD诊断。没有端到端的培训目标。本文提出了一种替代方法来解决上述方法,其中将AD诊断纳入了GAN培训目标中,以实现最佳的AD分类性能。根据歧视者的表现进行了微调,并稳定了整体训练。拟议的网络体系结构和培训制度显示了针对三类和四类广告分类任务的最新性能。

Positron Emission Tomography (PET) is now regarded as the gold standard for the diagnosis of Alzheimer's Disease (AD). However, PET imaging can be prohibitive in terms of cost and planning, and is also among the imaging techniques with the highest dosage of radiation. Magnetic Resonance Imaging (MRI), in contrast, is more widely available and provides more flexibility when setting the desired image resolution. Unfortunately, the diagnosis of AD using MRI is difficult due to the very subtle physiological differences between healthy and AD subjects visible on MRI. As a result, many attempts have been made to synthesize PET images from MR images using generative adversarial networks (GANs) in the interest of enabling the diagnosis of AD from MR. Existing work on PET synthesis from MRI has largely focused on Conditional GANs, where MR images are used to generate PET images and subsequently used for AD diagnosis. There is no end-to-end training goal. This paper proposes an alternative approach to the aforementioned, where AD diagnosis is incorporated in the GAN training objective to achieve the best AD classification performance. Different GAN lossesare fine-tuned based on the discriminator performance, and the overall training is stabilized. The proposed network architecture and training regime show state-of-the-art performance for three- and four- class AD classification tasks.

扫码加入交流群

加入微信交流群

微信交流群二维码

扫码加入学术交流群,获取更多资源