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OpenSBLI is an open-source code-generation system for compressible fluid dynamics (CFD) on heterogeneous computing architectures. Written in Python, OpenSBLI is an explicit high-order finite-difference solver on structured curvilinear meshes. Shock-capturing is performed by a choice of high-order Weighted Essentially Non-Oscillatory (WENO) or Targeted Essentially Non-Oscillatory (TENO) schemes. OpenSBLI generates a complete CFD solver in the Oxford Parallel Structured (OPS) domain specific language. The OPS library is embedded in C code, enabling massively-parallel execution of the code on a variety of high-performance-computing architectures, including GPUs. The present paper presents a code base that has been completely rewritten from the earlier proof of concept (Jacobs et al, JoCS 18 (2017), 12-23), allowing shock capturing, coordinate transformations for complex geometries, and a wide range of boundary conditions, including solid walls with and without heat transfer. A suite of validation and verification cases are presented, plus demonstration of a large-scale Direct Numerical Simulation (DNS) of a transitional Shockwave Boundary Layer Interaction (SBLI). The code is shown to have good weak and strong scaling on multi-GPU clusters. We demonstrate that code-generation and domain specific languages are suitable for performing efficient large-scale simulations of complex fluid flows on emerging computing architectures.