论文标题
酶趋化性和增强扩散的非平衡理论
Nonequilibrium theory of enzyme chemotaxis and enhanced diffusion
论文作者
论文摘要
在过去十年的几个实验中，已经报道了酶的增强扩散和抗肿瘤，在应用和基本水平上开辟了全新的生物纳米研究途径。在这里，我们介绍了一个新型的理论框架，该框架植根于催化周期的非平衡效应特征，该框架解释了迄今为止在该领域进行的所有观察结果。此外，我们的理论预测了完全新颖的效果，例如耗散诱导的抗化学和趋化性行为之间的切换。
Enhanced diffusion and anti-chemotaxis of enzymes have been reported in several experiments in the last decade, opening up entirely new avenues of research in the bio-nanosciences both at the applied and fundamental level. Here, we introduce a novel theoretical framework, rooted in non-equilibrium effects characteristic of catalytic cycles, that explains all observations made so far in this field. In addition, our theory predicts entirely novel effects, such as dissipation-induced switch between anti-chemotactic and chemotactic behavior.
