论文标题
长期致癌性生物测定中肿瘤发病率的多功能趋势测试
A versatile trend test for the evaluation of tumor incidences in long-term carcinogenicity bioassays
论文作者
论文摘要
为了评估致癌性生物测定，提出了一种新的趋势测试，该测试基于最大算术，序数和对数回归评分，以及对原油比例或更合适的poly3估算的Williams-type对比度，用于tumor-by-by-Time关系。该测试为大多数剂量反应关系形状提供了几乎适当的功能（包括在高（ER）剂量下可能的下降效果，显着性的常见迹象（P值，置信度限制）以及有关可能形状的信息。相关软件可在Cran-Packages TukeyTrend，McPan，MultComp中很容易获得。
For the evaluation of carcinogenicity bioassays a new trend test is proposed which is based on a maximum of arithmetic, ordinal, and logarithmic regression scores as well as the Williams-type contrasts for either crude proportions or more appropriate poly3-estimates for the tumor-by-time relationships. This test provides an almost appropriate power for most shapes of dose-response relationships (including for possible downturn effect at high(er) dose(s)), common signs of significance (p-value, confidence limits) and the information on the probable shape. Related software is easily available within the CRAN-packages tukeytrend, MCPAN, multcomp.
