论文标题

在右审查下进行分位数回归的深度学习:Deepquantreg

Deep Learning for Quantile Regression under Right Censoring: DeepQuantreg

论文作者

Jia, Yichen, Jeong, Jong-Hyeon

论文摘要

神经网络或深度学习的计算预测算法最近在统计数据以及图像识别和自然语言处理中引起了很多关注。特别是在审查生存数据的统计应用中,用于优化的损耗函数主要基于Cox的模型的部分可能性及其利用现有神经网络库(例如Keras)(例如Keras)的变化,例如Keras,keras是基于Tensorflow开源库构建的。本文介绍了神经网络对分位数回归的新颖应用,并使用正确的审查进行了生存数据,该数据通过检查功能中估计的审查分布的倒数来调整。这项工作的主要目的是表明,与现有的分位数回归方法相比,深度学习方法可以足够灵活,以更准确地预测非线性模式,例如传统的线性分位数回归和非参数分位数回归,并强调了该方法对审查生存数据的实用性。进行了仿真研究以生成非线性审查的生存数据,并将深度学习方法与现有的分位数回归方法进行比较。提出的方法用两个带有基因特征的公开可用的乳腺癌数据集说明了。该方法已内置在一个软件包中,并在\ url {https://github.com/yicjia/deepquantreg}中免费获得。

The computational prediction algorithm of neural network, or deep learning, has drawn much attention recently in statistics as well as in image recognition and natural language processing. Particularly in statistical application for censored survival data, the loss function used for optimization has been mainly based on the partial likelihood from Cox's model and its variations to utilize existing neural network library such as Keras, which was built upon the open source library of TensorFlow. This paper presents a novel application of the neural network to the quantile regression for survival data with right censoring, which is adjusted by the inverse of the estimated censoring distribution in the check function. The main purpose of this work is to show that the deep learning method could be flexible enough to predict nonlinear patterns more accurately compared to existing quantile regression methods such as traditional linear quantile regression and nonparametric quantile regression with total variation regularization, emphasizing practicality of the method for censored survival data. Simulation studies were performed to generate nonlinear censored survival data and compare the deep learning method with existing quantile regression methods in terms of prediction accuracy. The proposed method is illustrated with two publicly available breast cancer data sets with gene signatures. The method has been built into a package and is freely available at \url{https://github.com/yicjia/DeepQuantreg}.

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