论文标题
线虫早期胚胎发生的速度和命运多样性折衷
Speed and fate diversity tradeoff in nematode's early embryogenesis
论文作者
论文摘要
线虫物种在发育过程中以其不变的细胞谱系模式而闻名。结合了秀丽隐杆线虫中不对称分裂引起的命运规范以及细胞周期长度和细胞体积之间的抗相关性的知识，我们提出了一个模型，以通过改变每个分裂中的细胞体积隔离比来模拟谱系起始，并量化衍生的模式在增殖的速度，fate速度和空间稳健性中的衍生模式。发现秀丽隐杆线虫胚胎中的刻板印象是通过编程不对称分裂作为一种策略，是最佳的解决方案之一。
Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume in Caenorhabditis elegans, we propose a model to simulate lineage initiation by altering cell volume segregation ratio in each division, and quantify the derived pattern's performance in proliferation speed, fate diversity and space robustness. The stereotypic pattern in C. elegans embryo is found to be one of the most optimal solutions taking minimum time to achieve the cell number before gastrulation, by programming asymmetric division as a strategy.
