论文标题
固体汇合上皮中细胞 - 细胞连接的弹性，稳定性和准振荡
Elasticity, stability, and quasi-oscillations of cell-cell junctions in solid confluent epithelia
论文作者
论文摘要
生物组织的宏观特性和形状取决于微观尺度上细胞 - 细胞连接的重塑。我们提出了一个理论框架，该框架将固体汇合组织的顶点模型与描述交界性肌动蛋白中局部力偶极子产生的动力学结合。根据肌球蛋白的转变率，连接可以保留稳定的长度或塌陷以启动细胞重排。我们发现噪声可以扩大和维持瞬时振荡，从而产生准周期性连接动力学。我们还发现，连接稳定性受细胞排列和连接静止紧张的影响，这可能解释了胚胎收敛和延伸过程中的连接性崩溃。
Macroscopic properties and shapes of biological tissues depend on the remodelling of cell-cell junctions at the microscopic scale. We propose a theoretical framework that couples a vertex model of solid confluent tissues with the dynamics describing generation of local force dipoles in the junctional actomyosin. Depending on the myosin-turnover rate, junctions either preserve stable length or collapse to initiate cell rearrangements. We find that noise can amplify and sustain transient oscillations to the fixed point, giving rise to quasi-periodic junctional dynamics. We also discover that junctional stability is affected by cell arrangements and junctional rest tensions, which may explain junctional collapse during convergence and extension in embryos.
