论文标题
开关系统的离散时间MPC,并应用于生物医学问题
Discrete-time MPC for switched systems with applications to biomedical problems
论文作者
论文摘要
操纵控制动作的开关系统是时间间隔的切换信号描述了许多工程问题,主要与生物医学应用有关。在这种情况下,控制系统意味着在给定有限家庭中选择一个自主系统(在每个时间步骤)。即使可以通过解决动态编程(DP)问题来完成此选择,这种解决方案通常也很难应用,并且状态/控制约束无法明确考虑。在这项工作中,提出了一种新的基于集合的模型预测控制(MPC)策略来处理可拖动形式的开关系统。 MPC公式核心的优化问题包括一个易于解决的混合组合优化问题,该问题的解决方案以退缩的方式应用。模拟了两种生物医学应用以测试控制器:(i)衰减病毒突变和药物耐药性对病毒载量的影响的药物时间表,以及(ii)三重阴性乳腺癌治疗的药物时间表。数值结果表明,所提出的策略的表现优于可用治疗的时间表。
Switched systems in which the manipulated control action is the time-depending switching signal describe many engineering problems, mainly related to biomedical applications. In such a context, to control the system means to select an autonomous system - at each time step - among a given finite family. Even when this selection can be done by solving a Dynamic Programming (DP) problem, such a solution is often difficult to apply, and state/control constraints cannot be explicitly considered. In this work a new set-based Model Predictive Control (MPC) strategy is proposed to handle switched systems in a tractable form. The optimization problem at the core of the MPC formulation consists in an easy-to-solve mixed-integer optimization problem, whose solution is applied in a receding horizon way. Two biomedical applications are simulated to test the controller: (i) the drug schedule to attenuate the effect of viral mutation and drugs resistance on the viral load, and (ii) the drug schedule for Triple Negative breast cancer treatment. The numerical results suggest that the proposed strategy outperform the schedule for available treatments.