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The min-max optimization problem, also known as the saddle point problem, is a classical optimization problem which is also studied in the context of zero-sum games. Given a class of objective functions, the goal is to find a value for the argument which leads to a small objective value even for the worst case function in the given class. Min-max optimization problems have recently become very popular in a wide range of signal and data processing applications such as fair beamforming, training generative adversarial networks (GANs), and robust machine learning, to just name a few. The overarching goal of this article is to provide a survey of recent advances for an important subclass of min-max problem, where the minimization and maximization problems can be non-convex and/or non-concave. In particular, we will first present a number of applications to showcase the importance of such min-max problems; then we discuss key theoretical challenges, and provide a selective review of some exciting recent theoretical and algorithmic advances in tackling non-convex min-max problems. Finally, we will point out open questions and future research directions.