论文标题
神经肽SF（NPSF）的抗抑郁样作用
Antidepressant-like Effects of Neuropeptide SF (NPSF)
论文作者
论文摘要
神经肽SF（NPSF）是在中枢神经系统中起多种作用的RFAMIDE神经肽的成员。对NPSF对脑功能的影响知之甚少。在修饰的小鼠FST中研究了NPSF的抗抑郁样作用。 NPSF通过减少固定时间并增加攀登时间和游泳时间来显示出抗抑郁药样的作用。此外，在改良的小鼠FST中研究了肾上腺素能，血清素能，胆碱能或多巴胺能受体的参与。 Mice were pretreated with a non-selective α-adrenergic receptor antagonist phenoxybenzamine, a \b{eta}-adrenergic receptor antagonist, propranolol, a non-selective 5-HT2 serotonergic receptor antagonist, cyproheptadine, nonselective muscarinic acetylcholine receptor antagonist, atropine, or D2，D3，D4多巴胺受体拮抗剂，氟哌啶醇。目前的结果证实，NPSF的抗抑郁样作用至少部分是通过α-肾上腺素能，5-HT2血清素能，毒蕈碱乙酰胆碱受体和D2，D3，D3，D4多巴胺受体在修饰的小鼠FST中的相互作用的。
Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and swimming time. Furthermore, the involvement of the adrenergic, serotonergic, cholinergic or dopaminergic receptors in the antidepressant-like effect of NPSF was studied in modified mice FST. Mice were pretreated with a non-selective α-adrenergic receptor antagonist phenoxybenzamine, a \b{eta}-adrenergic receptor antagonist, propranolol, a non-selective 5-HT2 serotonergic receptor antagonist, cyproheptadine, nonselective muscarinic acetylcholine receptor antagonist, atropine, or D2, D3, D4 dopamine receptor antagonist, haloperidol. The present results confirmed that the antidepressant-like effect of NPSF is mediated, at least in part, by an interaction of the α-adrenergic, 5-HT2 serotonergic, muscarinic acetylcholine receptors and D2, D3, D4 dopamine receptor in a modified mouse FST.
