论文标题
集体细胞运动中的活性细胞间力
Active Inter-cellular Forces in Collective Cell Motility
论文作者
论文摘要
汇合细胞表的集体行为受到极力的强烈影响，通过细胞骨架推进和主动细胞间力产生，这些力是由跨细胞细胞连接的相互作用介导的。 We use a phase-field model to explore the interplay between these two contributions and compare the dynamics of a cell sheet when the polarity of the cells aligns to (i) their main axis of elongation, (ii) their velocity, and (iii) when the polarity direction executes a persistent random walk.In all three cases, we observe a sharp transition from a jammed state (where cell rearrangements are strongly suppressed) to a liquid state (where the当极性或细胞间力增加时，细胞可以彼此自由移动。另外，仅对于（ii），我们观察到大多数细胞沿相同方向移动的其他动力学状态，植入（固体或液体）。强烈的极性力量被认为是羊群的，但是随着细胞间活性的强度的增加而被破坏。
The collective behaviour of confluent cell sheets is strongly influenced both by polar forces, arising through cytoskeletal propulsion and by active inter-cellular forces, which are mediated by interactions across cell-cell junctions. We use a phase-field model to explore the interplay between these two contributions and compare the dynamics of a cell sheet when the polarity of the cells aligns to (i) their main axis of elongation, (ii) their velocity, and (iii) when the polarity direction executes a persistent random walk.In all three cases, we observe a sharp transition from a jammed state (where cell rearrangements are strongly suppressed) to a liquid state (where the cells can move freely relative to each other) when either the polar or the inter-cellular forces are increased. In addition, for case (ii) only, we observe an additional dynamical state, flocking (solid or liquid), where the majority of the cells move in the same direction. The flocking state is seen for strong polar forces, but is destroyed as the strength of the inter-cellular activity is increased.
