论文标题
为什么大多数Covid-19感染曲线是线性的?
Why are most COVID-19 infection curves linear?
论文作者
论文摘要
许多国家已经通过了他们的第一个Covid-19-19流行高峰。传统的流行病学模型将其描述为非药物干预措施的结果,该干预措施将增长率提高到恢复速率以下。在这个大流行的新阶段,许多国家显示,延长时间周期的确认病例几乎是线性的增长。传统模型很难解释这种新的遏制制度,在这种模型中,感染数量要么爆炸性地生长直到达到牛群免疫力,要么完全抑制流行病(零新病例)。在这里,我们根据接触网络的结构提供了这种令人困惑的观察的解释。我们表明,对于任何给定的传输率,存在关键的社会接触数量,$ d_c $,在此下方必须发生线性增长和低感染的患病率。以上$ d_c $传统流行病学动态发生了,例如在Sir-Type模型中。将我们的相应模型校准到传输速率的经验估计以及具有传染性天数时,我们发现$ d_c \ sim 7.2 $。假设具有约5度的现实接触网络,并且假设锁定措施将其减少到家庭大小(约2.5),则我们以显着的精度复制实际感染曲线,而无需拟合或调整参数。特别是我们比较了美国和奥地利,作为一个最初没有采取措施的一个国家的例子,并且在早期就以严重的锁定做出了反应。我们的发现质疑标准隔室模型描述COVID-19遏制阶段的适用性。观察它们的线性生长的可能性实际上为零。
Many countries have passed their first COVID-19 epidemic peak. Traditional epidemiological models describe this as a result of non-pharmaceutical interventions that pushed the growth rate below the recovery rate. In this new phase of the pandemic many countries show an almost linear growth of confirmed cases for extended time-periods. This new containment regime is hard to explain by traditional models where infection numbers either grow explosively until herd immunity is reached, or the epidemic is completely suppressed (zero new cases). Here we offer an explanation of this puzzling observation based on the structure of contact networks. We show that for any given transmission rate there exists a critical number of social contacts, $D_c$, below which linear growth and low infection prevalence must occur. Above $D_c$ traditional epidemiological dynamics takes place, as e.g. in SIR-type models. When calibrating our corresponding model to empirical estimates of the transmission rate and the number of days being contagious, we find $D_c\sim 7.2$. Assuming realistic contact networks with a degree of about 5, and assuming that lockdown measures would reduce that to household-size (about 2.5), we reproduce actual infection curves with a remarkable precision, without fitting or fine-tuning of parameters. In particular we compare the US and Austria, as examples for one country that initially did not impose measures and one that responded with a severe lockdown early on. Our findings question the applicability of standard compartmental models to describe the COVID-19 containment phase. The probability to observe linear growth in these is practically zero.