论文标题

用于开发数字干预措施的微型机制试验:实验设计注意事项

The Micro-Randomized Trial for Developing Digital Interventions: Experimental Design Considerations

论文作者

Walton, Ashley E., Collins, Linda M., Klasnja, Predrag, Nahum-Shani, Inbal, Rabbi, Mashfiqui, Walton, Maureen A., Murphy, Susan A.

论文摘要

即时的自适应干预措施(JITAI)是时间变化的自适应干预措施,使用频繁的机会来调整干预措施,例如每天,每天甚至每天很多次。数字技术能够连续收集有关个人当前环境并提供适合此信息的治疗的信息的能力,可以促进这种适应性的高强度。微型试验(MRT)已出现用于告知Jitais的构建。 MRTS在迅速变化的数字干预环境中运行并利用了MRT。 MRT可用于解决有关Jitai的特定组成部分是否有效的研究问题,其最终目标是开发有效,有效的组成部分。本文的目的是澄清为什么,何时以及如何使用MRT;强调在设计和实施捷运时必须考虑的要素;并讨论这种新兴优化试验设计为行为科学,教育和其他领域的未来研究提供的可能性。我们简要回顾了Jitais的关键要素,然后描述了MRT的三个案例研究,每种MRT都强调了可以使用可能出现的MRT和实验设计注意事项来解决的研究问题。我们还以案例研究为例,讨论了计划和设计捷运的各种考虑。

Just-in-time adaptive interventions (JITAIs) are time-varying adaptive interventions that use frequent opportunities for the intervention to be adapted such as weekly, daily, or even many times a day. This high intensity of adaptation is facilitated by the ability of digital technology to continuously collect information about an individual's current context and deliver treatments adapted to this information. The micro-randomized trial (MRT) has emerged for use in informing the construction of JITAIs. MRTs operate in, and take advantage of, the rapidly time-varying digital intervention environment. MRTs can be used to address research questions about whether and under what circumstances particular components of a JITAI are effective, with the ultimate objective of developing effective and efficient components. The purpose of this article is to clarify why, when, and how to use MRTs; to highlight elements that must be considered when designing and implementing an MRT; and to discuss the possibilities this emerging optimization trial design offers for future research in the behavioral sciences, education, and other fields. We briefly review key elements of JITAIs, and then describe three case studies of MRTs, each of which highlights research questions that can be addressed using the MRT and experimental design considerations that might arise. We also discuss a variety of considerations that go into planning and designing an MRT, using the case studies as examples.

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