论文标题
在硬壁电势通道中拉伸DNA
Stretching DNA in hard-wall potential channels
论文作者
论文摘要
使用三维介观模型来研究狭窄环境中短DNA链的特性。圆柱通道由哈密顿系统中的硬壁排斥潜力表示。宏观螺旋参数是计算出在微观碱基对波动的集合上执行统计平均值的计算。通过端到端距离测量的平均分子伸长率是均匀和异质链的通道电位参数的函数。总体结果表明，具有通道电势项的介观模型对短链的拉伸和扭曲产生一致的定量估计值。
A three dimensional mesoscopic model is applied to study the properties of short DNA chains in a confining environment. The cylindrical channel is represented by a hard-wall repulsive potential incorporated in the system Hamiltonian. The macroscopic helical parameters are computed performing statistical averages over the ensemble of microscopic base pair fluctuations. The average molecule elongation, measured by the end-to-end distance, is derived as a function of the channel potential parameters both for a homogeneous and a heterogeneous chain. The overall results suggest that the mesoscopic model, with the channel potential term, yields consistent quantitative estimates for the stretching and twisting of short chains.
