论文标题
泛氨基酮生物合成的细菌途径
Bacterial pathways for the biosynthesis of ubiquinone
论文作者
论文摘要
泛氨酮是蛋白质和真核生物中电子转移链的重要组成部分。泛氨基酮的生物合成需要多个步骤，其中大多数是细菌和真核生物常见的。尽管在真核生物中产生泛氨基酮的线粒体途径的酶非常相似，但最近的结果表明细菌中途径的多样性相当高。这篇综述着重于细菌中的泛氨基酮，突出了新发现的功能，并详细介绍了已知参与其生物合成途径的蛋白质。新的结果表明，泛氨基酮可以由独立于二恶英的途径产生，这表明泛氨基酮可能还会参与厌氧菌，除了其在多活检中的良好作用。我们还讨论了泛素酮生物合成蛋白的超分子组织，并总结了相对于其他异磷酸喹酮（如甲酸苯丙胺酮和plastoquinone）的泛氨基酮途径进化的当前理解。
Ubiquinone is an important component of the electron transfer chains in proteobacteria and eukaryotes. The biosynthesis of ubiquinone requires multiple steps, most of which are common to bacteria and eukaryotes. Whereas the enzymes of the mitochondrial pathway that produces ubiquinone are highly similar across eukaryotes, recent results point to a rather high diversity of pathways in bacteria. This review focuses on ubiquinone in bacteria, highlighting newly discovered functions and detailing the proteins that are known to participate to its biosynthetic pathways. Novel results showing that ubiquinone can be produced by a pathway independent of dioxygen suggest that ubiquinone may participate to anaerobiosis, in addition to its well established role for aerobiosis. We also discuss the supramolecular organization of ubiquinone biosynthesis proteins and we summarize the current understanding of the evolution of the ubiquinone pathways relative to those of other isoprenoid quinones like menaquinone and plastoquinone.
