论文标题
抗合性药物二乙基甘巴氨嗪对治疗Covid-19有用吗？
Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?
论文作者
论文摘要
SARS-COV-2病毒已导致Covid-19的毁灭性大流行。探索可以在治疗方面突破的化合物是小时的需要。重新定位便宜，免费提供和安全的药物是当务之急。本文提出了证据表明在COVID-19的治疗中可能使用二乙基甘巴马嗪（DEC）。 DEC对蛛网膜酸代谢对前列腺素有抑制作用，对动物逆转录病毒的鲜为人知的抗病毒作用鲜为人知，并在肺部炎症的动物模型中表现出抗炎作用，表明需要进一步探索这一假设。我们认为这是DEC第一次被提议治疗Covid-19。
The SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19.
