论文标题
SARS-COV-2的比较分析
A comparative analysis for SARS-CoV-2
论文作者
论文摘要
Covid-19极大地影响了世界。至关重要的是，生物学实验和临床设计是通过计算方法来告知时间和成本效益的解决方案的。比较分析特别可以发挥关键作用，可以揭示由于突变引起的蛋白质的结构变化，这可能导致行为变化，例如SARS-COV-2表面糖蛋白与人ACE2受体的结合增加。该报告的目的是为生物学家和其他人提供易于关注的教程，而无需研究不同的生物信息学工具。然后可以利用更复杂的分析，例如使用大规模计算方法。从SARS-COV-2基因组序列开始，该报告显示了可视化的DNA序列特征，得出氨基酸序列以及对齐不同的基因组以分析突变和差异。该报告提供了有关SARS-COV-2表面糖蛋白如何通过整合现有的3D蛋白模型的SARS-COV蛋白而突变的SARS-COV-2表面糖蛋白如何突变的SARS-COV-2表面糖蛋白。
COVID-19 has affected the world tremendously. It is critical that biological experiments and clinical designs are informed by computational approaches for time- and cost-effective solutions. Comparative analyses particularly can play a key role to reveal structural changes in proteins due to mutations, which can lead to behavioural changes, such as the increased binding of the SARS-CoV-2 surface glycoprotein to human ACE2 receptors. The aim of this report is to provide an easy to follow tutorial for biologists and others without delving into different bioinformatics tools. More complex analyses such as the use of large-scale computational methods can then be utilised. Starting with a SARS-CoV-2 genome sequence, the report shows visualising DNA sequence features, deriving amino acid sequences, and aligning different genomes to analyse mutations and differences. The report provides further insights into how the SARS-CoV-2 surface glycoprotein mutated for higher binding affinity to human ACE2 receptors, compared to the SARS-CoV protein, by integrating existing 3D protein models.
