论文标题

使用多视图表示学习映射皮层体系结构的个体差异

Mapping individual differences in cortical architecture using multi-view representation learning

论文作者

Sellami, Akrem, Dupé, François-Xavier, Cagna, Bastien, Kadri, Hachem, Ayache, Stéphane, Artières, Thierry, Takerkart, Sylvain

论文摘要

在神经科学中,了解个体间差异最近已成为一个主要挑战,对此功能性磁共振成像(fMRI)已被证明是无价的。为此,神经科学家依靠基本方法,例如单个大脑特征和分数之间的单变线性相关性和量化疾病的严重程度或受试者在认知任务中的表现。但是,到目前为止,由于缺乏有效合并它们的方法,因此已为此问题分别利用了Task-FMI和静止状态fMRI。在本文中,我们引入了一种新颖的机器学习方法,该方法允许通过这两个fMRI协议分别结合基于激活和基于连接的信息,以识别大脑功能组织中个体差异的标记。它结合了一个多视图深度自动编码器,该自动编码器旨在将两个fMRI模式融合到关节表示空间中,在该空间中,训练了预测模型,以猜测表征患者的标量分数。我们的实验结果表明,所提出的方法胜过竞争性方法并产生可解释和生物学上合理的结果的能力。

In neuroscience, understanding inter-individual differences has recently emerged as a major challenge, for which functional magnetic resonance imaging (fMRI) has proven invaluable. For this, neuroscientists rely on basic methods such as univariate linear correlations between single brain features and a score that quantifies either the severity of a disease or the subject's performance in a cognitive task. However, to this date, task-fMRI and resting-state fMRI have been exploited separately for this question, because of the lack of methods to effectively combine them. In this paper, we introduce a novel machine learning method which allows combining the activation-and connectivity-based information respectively measured through these two fMRI protocols to identify markers of individual differences in the functional organization of the brain. It combines a multi-view deep autoencoder which is designed to fuse the two fMRI modalities into a joint representation space within which a predictive model is trained to guess a scalar score that characterizes the patient. Our experimental results demonstrate the ability of the proposed method to outperform competitive approaches and to produce interpretable and biologically plausible results.

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