论文标题

使用对象分割和卷积神经网络的早产阶段诊断的视网膜病变

Retinopathy of Prematurity Stage Diagnosis Using Object Segmentation and Convolutional Neural Networks

论文作者

Ding, Alexander, Chen, Qilei, Cao, Yu, Liu, Benyuan

论文摘要

早产视网膜病变(ROP)是一种主要影响体重较低的过早婴儿的眼睛疾病。它导致视网膜中血管的扩散,并可能导致视力丧失,并最终导致视网膜脱离,导致失明。尽管人类专家可以轻松地确定ROP的严重阶段,但与确定治疗选择最相关的较早阶段的诊断受到人类专家的主观解释的可变性的影响更大。近年来,已经付出了巨大的努力来使用深度学习来自动化诊断。本文建立在先前模型的成功基础上,并开发了一种新颖的体系结构,该结构结合了对象分割和卷积神经网络(CNN),以基于新生儿视网膜图像构建ROP阶段的有效分类器。由于视网膜中划界线的形成和形状是较早的ROP阶段之间的区别特征,我们的提议的系统首先训练对象分割模型,以在像素级别识别分界线,并将结果掩码添加为原始图像中的附加“颜色”通道。然后,系统基于处理的图像训练CNN分类器,以利用原始图像和掩码的信息,这有助于将模型的注意力引向分界线。在许多仔细的实验​​中,将其性能与先前对象分割系统和在数据集中训练的仅CNN系统进行了比较时,我们的新型体系结构在准确性方面显着优于先前的系统,证明了我们提出的管道的有效性。

Retinopathy of Prematurity (ROP) is an eye disorder primarily affecting premature infants with lower weights. It causes proliferation of vessels in the retina and could result in vision loss and, eventually, retinal detachment, leading to blindness. While human experts can easily identify severe stages of ROP, the diagnosis of earlier stages, which are the most relevant to determining treatment choice, are much more affected by variability in subjective interpretations of human experts. In recent years, there has been a significant effort to automate the diagnosis using deep learning. This paper builds upon the success of previous models and develops a novel architecture, which combines object segmentation and convolutional neural networks (CNN) to construct an effective classifier of ROP stages 1-3 based on neonatal retinal images. Motivated by the fact that the formation and shape of a demarcation line in the retina is the distinguishing feature between earlier ROP stages, our proposed system first trains an object segmentation model to identify the demarcation line at a pixel level and adds the resulting mask as an additional "color" channel in the original image. Then, the system trains a CNN classifier based on the processed images to leverage information from both the original image and the mask, which helps direct the model's attention to the demarcation line. In a number of careful experiments comparing its performance to previous object segmentation systems and CNN-only systems trained on our dataset, our novel architecture significantly outperforms previous systems in accuracy, demonstrating the effectiveness of our proposed pipeline.

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