论文标题
具有高速和高分辨率傅立叶全场光学相干断层扫描的人角膜的体内成像
In vivo imaging of human cornea with high-speed and high-resolution Fourier-domain full-field optical coherence tomography
论文作者
论文摘要
眼科评估的角膜评估需要细胞分辨率和快速成像技术，才能准确诊断。目前，最快的体积成像技术是使用快速相机和快速调谐激光源的傅立叶全场光学相干断层扫描（FD-FF-OCT）。在这里，我们展示了带有FD-FF-OCT的高分辨率，高速，非接触角膜体积成像，该成像可以获取单个3D体积，体素速率为7.8 GHz。激光源的空间相干性被抑制，以防止其聚焦到视网膜上的位置，因此超过了最大允许的暴露（MPE）。 FD-FF-OCT数据的固有体积性质使弯曲的角膜层具有扁平化。获得的FD-FF-OCT图像揭示了角膜细胞结构，例如上皮，基质和内皮，以及脊髓和层神经。
Corneal evaluation in ophthalmology necessitates cellular-resolution and fast imaging techniques allowing accurate diagnoses. Currently, the fastest volumetric imaging technique is Fourier-domain full-field optical coherence tomography (FD-FF-OCT) that uses a fast camera and a rapidly tunable laser source. Here, we demonstrate high-resolution, high-speed, non-contact corneal volumetric imaging in vivo with FD-FF-OCT that can acquire a single 3D volume with a voxel rate of 7.8 GHz. The spatial coherence of the laser source was suppressed to prevent it from focusing to a spot on the retina, and therefore, exceeding the maximum permissible exposure (MPE). Inherently volumetric nature of FD-FF-OCT data enabled flattening of curved corneal layers. Acquired FD-FF-OCT images revealed corneal cellular structures, such as epithelium, stroma and endothelium, as well as subbasal and mid-stromal nerves.
