论文标题
基于活检选择的预后和组织学特征之间的相关性变化
Variation in correlation between prognosis and histologic feature based on biopsy selection
论文作者
论文摘要
胶质母细胞瘤的多形带有令人沮丧的预后，对黄金标准治疗的反应不佳。已经开发了创新的数据分析方法来表征具有组织学特征的肿瘤基因组表达。在临床环境中，活检选择方法可能会受到患者的时间和经济负担来限制。因此，我们研究了活检选择对35例GBM患者预后和组织学特征之间相关性的影响。我们比较了使用有限的体积，中等体积和Enblock肿瘤体积的方法。此外，我们研究了随机和战略方法对有限和中等体积活检的影响。最后，我们通过选择一到五个小活检来比较相关结果。我们观察到在选择方法之间的相关意义范围很广。这些发现可能有助于GBM的临床管理，并进行开发和部署目标疗法所需的更好的活检选择。
Glioblastoma multiform carries a dismal prognosis with poor response to gold standard treatment. Innovative data analysis methods have been developed to characterize tumor genomic expression with histologic features. In a clinical setting, biopsy selection methods may be constrained by time and financial burden to the patient. Thus, we investigate the impact biopsy selection has on correlation between prognostic and histologic features in 35 patients with GBM. We compared methods using limited volumes, moderate volumes, and enblock tumor volumes. Additionally, we investigated the impact of random versus strategic methods for limited and moderate volume biopsies. Finally, we compared correlation results by selecting one to five small biopsy. We observed a wide range in correlation significance across selection methods. These findings may aid clinical management of GBM and direct better biopsy selection necessary for the development and deployment of targeted therapies.
