论文标题
普雷斯汀的频率依赖性：内在过渡速率和粘弹性松弛
Frequency dependence of prestin: Intrinsic transition rates and viscoelastic relaxation
论文作者
论文摘要
内耳中的外毛细胞对于哺乳动物耳朵的灵敏度，频率选择性和动态范围很重要。认为外毛细胞的这种生理作用被认为是基于这些细胞的放大作用，这些细胞具有机械敏感的头发束和运动细胞体嵌入prestin，prestin是一种具有高密度机电偶联的膜蛋白。先前根据一个假设该运动蛋白的内在过渡速率比工作频率快，以前评估了外毛细胞的机械功率。该报告通过纳入运动膜蛋白的内在过渡速率来概括先前的处理。发现过渡速率减弱了外毛细胞的机械功率产生，因此粘性阻力不能超出门控的特征频率。
Outer hair cells in the inner ear is important for the sensitivity, frequency selectivity, and dynamic range of the mammalian ear. Such a physiological role of outer hair cells is thought to be based an amplifying effect of those cells, which have mechanosensitive their hair bundles and motile cell body embedding prestin, a membrane protein with electromechanical coupling at high density. Mechanical power production by outer hair cells were previously evaluated based on an assumption that the intrinsic transition rates of this motile protein is faster than the operating frequency. This report generalizes the previous treatment by incorporating intrinsic transition rates of the motile membrane protein. It was found that the transition rates attenuates mechanical power production of an outer hair cell such that viscous drag cannot be counteracted beyond the characteristic frequency of gating.
