论文标题
能量控制是必不可少的：生物物理杂志的新且值得注意的注释
Energetic Controls are Essential: New and Notable Note for Biophysical Journal
论文作者
论文摘要
Mikhail Shapiro的实验室通过选择性加热纳米颗粒，研究了一种有希望的新方法，可通过选择性加热神经系统中单个细胞中的钙电流，并表明简单的物理定律适当地应用，解释正在发生的事情，因此可以成为构建改进的方法和技术的基础。他们使用自定义的仪器和详细的定量测量来表明不需要特殊的表面特性来解释其结果。他们的工作被视为在生物物理学和生物学中需要定量测量的一个例子。引用了经典示例，并提出了结构和分子生物学的成功，这隐藏了对定量测量和控制的需求。半导体和计算电子被认为是一门比依赖定量测量，控制和分析的结构和分子生物学更成功的科学。
Mikhail Shapiro's lab investigated a promising new method for non-invasive control of calcium currents in individual cells in the nervous system by the selective heating of nanoparticles and show that simple physical laws, properly applied, explain what is happening, and so can be a foundation for constructing improved methods and techniques. They use custom built instrumentation and detailed quantitative measurement to show that special surface properties are not needed to explain their results. Their work is taken as an example of the need for quantitative measurement in biophysics and biology in general. Classical examples are cited and the argument is made that the success of structural and molecular biology has hidden the need for quantitative measurements and controls. Semiconductor and computational electronics is cited as a science even more successful than structural and molecular biology that depends on quantitative measurement, controls, and analysis.
