论文标题
模型脂质 - 胆固醇聚集的筏状结构域的形成
Raft-like domain formation in model lipid-cholesterol aggregation
论文作者
论文摘要
为了了解细胞膜分室化的机制，我们研究了由脂质和胆固醇分子组成的粗粒模型系统。胆固醇在双层脂质膜中的侧相分离中起着至关重要的作用，形成富含胆固醇的液体有序结构域，称为“筏”。在这项NVT分子动力学仿真研究中，我们研究了胆固醇在筏样形成中的作用。该研究表明，胆固醇相互作用的强度是形成胆固醇富含结构域的相分离背后的重要因素，而脂质和胆固醇分子的相对偶极强度控制了多双层堆栈的形成。
To understand mechanism of cell-membrane compartmentalization, we studied coarse-grained model systems consisting of lipid and cholesterol molecules. Cholesterol plays crucial role in lateral phase segregation in the bilayered lipid membrane to form cholesterol rich liquid ordered domains, termed as `rafts'. In this NVT Molecular Dynamics simulation study, we have investigated the role of cholesterol in raft-like domain formation. The study reveals that the strength of cholesterol interaction is an important factor behind the phase segregation to form cholesterol rich domains, whereas, the relative dipolar strength of lipid and cholesterol molecules controls the formation of multi-bilayered stack.
