学术文献库

There is considerable theoretical and experimental support to the proposal that tissue homeostasis in the adult skin can be represented as a critical branching process. The homeostatic condition requires that the proliferation rate of the progenitor (P) cells (capable of cell division) is counterbalanced by the loss rate due to the differentiation of a P cell into differentiated (D) cells so that the total number of P cells remains constant. We consider the two-branch and three-branch models of tissue homeostasis to establish homeostasis as a critical phenomenon. It is first shown that some critical branching process theorems correctly predict experimental observations. A number of temporal signatures of the approach to criticality are investigated based on simulation and analytical results. The analogy between a critical branching process and mean-field percolation and sandpile models is invoked to show that the size and lifetime distributions of the populations of P cells have power-law forms. The associated critical exponents have the same magnitudes as in the cases of the mean-field lattice statistical models. The results indicate that tissue homeostasis provides experimental opportunities for testing critical phenomena.