论文标题
颅内动脉瘤中的非kolmogorov湍流和逆能级联反应：近壁尺度表明机械生物学相关性
Non-Kolmogorov Turbulence and Inverse Energy Cascade in Intracranial Aneurysm: Near-Wall Scales Suggest Mechanobiological Relevance
论文作者
论文摘要
颅内动脉瘤（IA）的起源，生长和破裂是神经血管中的开放性问题，直到当下。动脉瘤的机械生物学和病理生物学的复杂性惊人地结合了紧密连接的生物学和物理过程。最近，人们认为血液流动中的湍流过渡在IA生长和破裂中起着核心作用，因为它可以与内皮功能障碍直接相关。但是，湍流问题为该主题带来了前所未有的并发症。我们发现IA中的湍流是非kolmogorov类型的。我们第一次检测到血流和非kolmogorov湍流中的动力学级联反应。在这里，我们假设经历反向能量级联的近壁湍流具有可能影响内皮细胞机械信号的尺度。我们的发现可能是当代动脉瘤血液动力学理论的范式转变。
The genesis, growth and rupture of intracranial aneurysm (IA) are open questions in neurovascular medicine until the present moment. The complexity of aneurysm mechanobiology and pathobiology staggeringly combine intertwining biological and physical processes that are tightly connected. Recently, transition to turbulence in IA blood flow is thought to play a central role in IA growth and rupture as it can be directly linked to endothelial dysfunction. However, the problem of turbulence brings unprecedented complications to the topic. We found turbulence in IA to be of non-Kolmogorov type. For the first time, we detected inverse kinetic energy cascade in blood flow and in non-Kolmogorov turbulence. Here, we hypothesize that the near-wall turbulence undergoing inverse energy cascade have scales that could affect the mechano-signaling of endothelial cells. Our findings could be a paradigm shift in the contemporary theory of aneurysm hemodynamics.
