论文标题

线性非线性泊松级别级联模型的尖峰火车累积物

Spike Train Cumulants for Linear-Nonlinear Poisson Cascade Models

论文作者

Kordovan, Michael, Rotter, Stefan

论文摘要

皮质网络中的尖峰活动本质上是非线性的。线性非线性级联模型,其中一些版本也称为点过程广义线性模型,可以有效捕获此类网络所展示的非线性动力学。在此类模型中特别感兴趣的是尖峰火车统计的理论预测。但是,由于瞬间关闭问题,近似值是不可避免的。我们在这里建议进行一系列扩展,以解释高阶时刻对较低阶段的夫妇的方式。我们的方法根据某些积分,即所谓的循环积分做出了预测。在先前的研究中,这些积分已通过数值评估,但是数值不稳定性有时会遇到结果不可靠。这里提出了分析解决方案,以克服这个问题,并进行更强大的评估。我们能够通过切换到傅立叶空间并利用复杂分析,特别是库奇的残基定理来推断这些分析解决方案。我们正式化了循环积分,并明确求解了特定响应函数。为了量化这些校正对于尖峰列车累积物的重要性,我们对尖峰网络进行了数值模拟,并将其样本统计数据与我们的理论预测进行了比较。我们的结果表明,非线性校正的大小取决于非线性网络动力学的工作点,并且与平均场稳定性矩阵的特征值有关。就我们的示例而言,射击率的校正平均在4%至21%之间。例如,对非线性影响的尖峰列车统计数据的精确预测与涉及涉及峰值依赖性可塑性(STDP)的理论高度相关。

Spiking activity in cortical networks is nonlinear in nature. The linear-nonlinear cascade model, some versions of which are also known as point-process generalized linear model, can efficiently capture the nonlinear dynamics exhibited by such networks. Of particular interest in such models are theoretical predictions of spike train statistics. However, due to the moment-closure problem, approximations are inevitable. We suggest here a series expansion that explains how higher-order moments couple to lower-order ones. Our approach makes predictions in terms of certain integrals, the so-called loop integrals. In previous studies these integrals have been evaluated numerically, but numerical instabilities are sometimes encountered rendering the results unreliable. Analytic solutions are presented here to overcome this problem, and to arrive at more robust evaluations. We were able to deduce these analytic solutions by switching to Fourier space and making use of complex analysis, specifically Cauchy's residue theorem. We formalized the loop integrals and explicitly solved them for specific response functions. To quantify the importance of these corrections for spike train cumulants, we numerically simulated spiking networks and compared their sample statistics to our theoretical predictions. Our results demonstrate that the magnitude of the nonlinear corrections depends on the working point of the nonlinear network dynamics, and that it is related to the eigenvalues of the mean-field stability matrix. For our example, the corrections for the firing rates are in the range between 4 % and 21 % on average. Precise and robust predictions of spike train statistics accounting for nonlinear effects are, for example, highly relevant for theories involving spike-timing dependent plasticity (STDP).

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