ISO INTERNATIONAL STANDARD 8466-2 Second edition 2001-11-01 Water quality Calibration and evaluation of analytical methods and estimation of performance characteristics Part 2: Calibration strategy for non-linear second-order calibration functions QualitedeI'eau-Etalonnageetévaluationdesmethodesd'analyseet estimationdescaracteresdeperformance Partie 2:Strategie d'etalonnagepourfonctions d'etalonnage non lineaires du second degré Reference number ISO 8466-2:2001(E) SO @ISO2001 ISO8466-2:2001(E) PDF disclaimer This PDF file may contain embedded typefaces. In accordance with Adobe's licensing policy, this file may be printed or viewed but shall not be edited unless the typefaces which are embedded are licensed to and installed on the computer performing the editing. In downloading this file, parties accept therein the responsibility of not infringing Adobe's licensing policy. The ISO Central Secretariat accepts no liability in this area. Adobe is a trademark of Adobe Systems Incorporated. Details of the software products used to create this PDF file can be found in the General Info relative to the file; the PDF-creation parameters were optimized for printing. Every care has been taken to ensure that the file is suitable for use by IsO member bodies. In the unlikely event ISO2001 All rights reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying and microfilm, without permission in writing from either ISO at the address below or ISO's member body in the country of the requester. ISO copyright office Casepostale56.CH-1211Geneva20 Tel. + 41 22 749 0111 Fax + 41 22 749 09 47 E-mail [email protected] Web www.iso.ch Printed in Switzerland ii @ ISO 2001 - All rights reserved ISO8466-2:2001(E) Contents Page Foreword.. .iv 1 Scope 2 Symbols, 3 Performance... 3.1 Choice of working range. 3.2 Testforthehomogeneity of thevariances 3.3 Measurement......... 4 Estimationof thepolynomial coefficients ... 5 Performance characteristics .... 5.1 Residual standard deviation.. 5.2 Instrument sensitivityof theanalytical procedure 5.3 Standard deviation of the procedure.... 5.4 Relativestandard deviation oftheprocedure Analysisofasample.. 6 6.1 General considerations. 6.2 Testforminimaormaxima. .6 6.3 Calculation of the analytical result.. 6.4 Confidence interval of the analytical result (see Figure 1). 7 Example... 7.1 Calibration,performance characteristics and evaluation. 7.2 Single measurement analysis. Annex A (normative) F-table (99 %) 10 Bibliography 12 @ IS0 2001 - All rights reserved ii ISO 8466-2:2001(E) Foreword IsO (the International Organization for Standardization)is a worldwide federation of national standards bodies (IsO Commission(lEC)onallmattersofelectrotechnicalstandardization International Standards are drafted in accordance with the rules given in the ISO/lEC Directives, Part 3. Draft International Standards adopted by the technical committees are circulated to the member bodies for voting Publication as an International Standard requires approval by at least 75 % of the member bodies casting a vote International Standard ISO 8466-2 was prepared by Technical Committee ISO/TC 147,Water quality, Subcommittee SC 2, Physical, chemical, biochemical methods. This second edition cancels and replaces the first edition (IsO 8466-2:1993), which has been technically revised. IsO8466 consists of thefollowing parts,underthegeneral title Water quality-Calibrationand evaluation of analyticalmethodsandestimationofperformancecharacteristics Part1:Statisticalevaluationofthelinearcalibrationfunction —Part 2:Calibration strategyfornon-linear second-ordercalibrationfunctions Annex A forms an integral part of this part of iSO 8466. iv @ ISO 2001 All rights reserved INTERNATIONALSTANDARD ISO 8466-2:2001(E) Water quality - Calibration and evaluation of analytical methods and estimation of performance characteristics Part 2: Calibration st