ISO/TR TECHNICAL REPORT 12845 First edition 2010-08-01 Selected illustrations of fractional factorial screening experiments Illustrations choisies de plans d'expériences factoriels fractionnaires Reference number ISO/TR 12845:2010(E) @ ISO 2010 Provided by IHS from IHS Not for Resale ISO/TR 12845:2010(E) PDFdisclaimer This PDF file may contain embedded typefaces. In accordance with Adobe's licensing policy, this file may be printed or viewed but shall not be edited unless the typefaces which are embedded are licensed to and installed on the computer performing the editing. In accepts no liability in this area. Adobe is a trademark of Adobe Systems Incorporated. Details of the software products used to create this PDF file can be found in the General Info relative to the file; the PDF-creation parameters were optimized for printing. Every care has been taken to ensure that the file is suitable for use by IsO member bodies. In the unlikely event that a problem relating to it is found, please inform the Central Secretariat at the address given below COPYRIGHT PROTECTED DOCUMENT ISO2010 All rights reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized in any form or by any means isO's member body in the country of the requester. ISO copyright office Case postale 56 . CH-1211 Geneva 20 Tel. + 41 22 749 01 11 Fax + 41 22 749 09 47 E-mail [email protected] Web www.iso.org Published in Switzerland ii @ ISO 2010 - All rights reserved Provided by IHS Not for Resale ISO/TR 12845:2010(E) Contents Page Foreword Introduction 1 Scope 2 Normative references 3 Terms and definitions 4 Symbolsandabbreviatedterms... 5 Generic description of fractional factorial designs .... 5.1 Overview of the structure of the examples in Annexes A to F 5.2 Overall objective(s) of the experiment (Step 1) .... 5.3 Response variabie(s) (Step 2).... 5.4 Factors affecting the response(s) (Step 3) . 5.5 Select a fractional factorial design (Step 4). 5.6 Analyse the results Numerical summaries and graphical displays (Step 5) 5.7 Present the findings (Step 6).... 5.8 Perform confirmation runs (Step 7). 6 Description of Annexes A to F... 6.1 Comparing and contrasting the examples. 6.2 Experiment summaries. .8 Annex A (informative) Direct mail marketing campaign ... 10 Annex B (informative) Optimizing a polymer emulsion 20 Annex C (informative) Insight into PvC foam formulations 34 Annex D (informative) Process validation for an insulin product.. 47 Annex E (informative) Washing machine experiment, Annex F (informative) Aggregated shipworm bacterium 72 Bibliography.. 80 IsO 2010-All rights reserved ii Provided by IHS ted without license from IHS Not for Resale ISO/TR 12845:2010(E) Foreword IsO (the International Organization for Standardization) is a worldwide federation of national standards bodies technicalcommittees.Eachmemberbodyinterestedinasubjectforwhichatechnicalcommitteehasbeer established has the right to be represented on that committee. International organizations, governmental and International Standards are drafted in accordance with the rules given in the ISO/lEc Directives, Part 2 The main task of technical committees is to prepare International Standards. Draft International Standards adopted by the technical committees are circulated to the member bodies for voting. Publication as an International Standard requires approval by at least 75 % of the member bodies casting a vote. In exceptional circumstances, when a technical committee has collected data of a different kind from that informative in nature and does not have to be reviewed until the data it provides are considered to be no longer valid or useful. Attention is drawn to the possibility that some of the elements of this document may be the subject of patent rights. IsO shall not be held responsible for identifying any or all such patent rights. ISO/TR 12845 was prepared by Technical Committee ISO/TC 69, Applications of statistical methods, Subcommittee S