ISO/TR TECHNICAL REPORT 14735 First edition 2013-04-15 Cosmetics Analytical methods - Nitrosamines: Technical guidance document for minimizing and determining N-nitrosamines in cosmetics Cosmetiques Méthodes analytiques - Nitrosamines: Directives techniques concernant la limitation et le dosage des N-nitrosamines dans les produits cosmétiques Reference number IS0/TR14735:2013(E) ISO @IS02013 No repr ed without license from IHS IS0/TR 14735:2013(E) COPYRIGHTPROTECTEDDOCUMENT @ISO2013 All rights reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below or ISO's member body in the country of the requester. ISO copyright office Case postale 56 : CH-1211 Geneva 20 Tel. + 41 22 749 01 11 Fax +41 22 749 09 47 E-mail [email protected] Web www.iso.org Published in Switzerland @ IS0 2013 - All rights reserved 44001, User=sharabiani, shahramfs or networking permited without license from IHS IS0/TR 14735:2013(E) Contents Page Foreword ..iv Introduction. .V 1 Scope. 2 N-nitrosamine chemistry. ..1 3 Minimization strategies. 3.1 Reduction or elimination of adventitious nitrite sources 1 3.2 Avoidance of other secondary amino sources. .2 3.3 Incorporation of inhibitors of nitrosamine formation 2 3.4 PotentialtreatmentofcosmeticrawmaterialsforN-nitrosaminesdecomposition 2 4 Analytical methods .3 4.1 Screen cosmetic products for N-nitroso compounds by chemiluminescent detection of nitric oxide 3 4.2 Apparent total nitrosamine content (ATNC) 3 4.3 Methods for NDELA .3 4.4 Determination of other specific N-nitrosamines .5 5 Analytical approach .5 5.1 General .5 5.2 Screening. .5 5.3 Measurement of specific N-nitrosamines .5 Annex A (informative) Compounds reported to act as inhibitors .7 Bibliography 8 iii se with IS thout license from IHS Notfor